While some residents are taking the bridge closure in stride - Steve Clay of St. Albans said it's the "price of progress," - others are not so laid back.
"It's going to be a hell of an inconvenience," said Randy Wheeler, 55, of Nitro.
Wheeler, who works at C&O Motors in St. Albans, can see the car dealership from his backyard. With the bridge open, his commute takes less than five minutes.
The drive will get significantly longer once the bridge closes because he will either have to drive to Dunbar and cross the Dunbar-South Charleston bridge to reach MacCorkle Avenue, or drive through Nitro to reach Interstate 64.
"It adds about 25 minutes if I go to Dunbar, but they have wrecks (on the interstate) every day," he said.
Wheeler said although the bridge closure will be inconvenient, he knows the transportation department is "doing what they need to do."
"It's trash. Go underneath of it. You can see the rust," he said.
Don Kereston, who lives on Sattes Circle in Nitro, holds a similar view.
"It's an inconvenience that I think needs done. We'll just have to grit our teeth and bear it," he said.
Kereston, 66, is a manager for Snyder's of Berlin, and splits his time between the potato chip company's offices in Ashland and Cross Lanes. The bridge closure will not affect his commute - he usually just drives through Nitro to pick up Interstate 64 - but Kereston said he and his wife usually drive into St. Albans to buy groceries and run other errands
He said they will just have to switch to stores on their side of the Kanawha River.
"What are you going to do?" he said. "It's not like they just told us yesterday."
Plans to replace the bridge were finalized last February, and work underneath the bridge has been under way since March. Most of that work has taken place below the water line as construction crews strengthened the bridge's current piers so they can support the new three-land deck that will be constructed this year.
As part of the $24 million project, the current bridge will be demolished and a new bridge will then be floated down the river and set on the newly reinforced piers.
The Nitro-St. Albans Bridge was opened in 1934, and has been concerned transportation officials for some time. In 2008 the weight limit was reduced from 14 to 12 tons, meaning KRT buses and some commercial vehicles could no longer use the span.