West Virginia University Extension Agent Dave Roberts said he and his children plan to dress up for the event.
"I think it's important to get the community involved and aware of some of the different services the health department has," he said.
"We've done several of the POD drills in the past, and it's hard to catch the public's attention. I believe preparing for a zombie apocalypse will get their attention."
Area police, ambulances and emergency services will be on hand to take part in the exercise, as well.
The federal Centers for Disease Control and Prevention launched a "tongue-in-cheek" zombie apocalypse campaign two years ago to engage new audiences with preparedness messages, according to its website.
The platform turned out to be effective, and they continue to reach audiences about hazard preparedness.
Ali Khan, U.S. assistant surgeon general and director of the Office of Public Health Preparedness and Response, said on their website, "If you are generally well equipped to deal with a zombie apocalypse, you will be prepared for a hurricane, pandemic, earthquake, or terrorist attack."
The exercise will take place from 10 a.m. to 1 p.m. Saturday at Scott High School in Boone County. The event is open to the public. For more information, contact Lisa Holstein with the Boone County Health Department at 304-369-7967.