After forcing a Black Eagles punt, Spring Valley cracked the end zone with a four-play, 52-yard drive, capped by George's 35-yard run.
SC answered on its next possession when Ken Haynes darted in from 19 yards out. A two-point conversion pass from Jon Alexander to Honore Dean gave the Black Eagles an 8-7 lead with 3:47 left in the quarter.
Wellman answered less than two minutes later with his 51-yard jaunt to give Spring Valley a 14-8 advantage.
South Charleston appeared to have regained some momentum when sophomore Daniel McAllister recovered a muffed punt at the Spring Valley 36.
After driving to the Spring Valley five yard line, Haynes appeared to have scored his second touchdown, but fumbled into the end zone where the Timberwolves' Colby Webb fell on it for a touchback.
The Black Eagles next possession ended when Alexander fumbled at the Timberwolves' six yard line with just over three minutes to play in the half.
"There were two times that we got ourselves into good scoring position in the first half and we totally screwed them up," said Messinger. "It was kind of our own fault because we shot ourselves in the foot, but at the end of the day, they forced us into them and just physically beat us up.
"We're a little banged up right now, but the worst hurting about us right now is our feelings."
The second half wasn't much better for the Black Eagles, who fumbled for the third straight possession after receiving the second half kickoff. Haynes fumbled on a third down carry at the Black Eagles' 38 yard line setting up a two-yard plunge by Wellman to give Spring Valley a 21-8 advantage with 8:02 left in the quarter.
SC cut the lead to 21-16 on its next possession with an 11-play, 65 yard drive capped by a five yard run by A.D. Cunningham.
Wellman answered with his 1-yard run to open the lead to 29-16, before Cunningham cut the lead to 29-22 with a 3-yard run with 2 seconds to play in the third.
Spring Valley stretched its lead to 37-22 early in the fourth quarter on a three run TD run and two point conversion run by Wellman.
Things looked bad for the Black Eagles when a tipped Alexander pass was intercepted by Corey Hughart, setting the Timberwolves up at its own 43 yard line, but a Robertson fumble on the first play was scooped up by Travond Reese and returned 64-yards for a score to get SC to within 37-28 with 9:17 to play.
Wellman fumbled at the SC 15-yard line on the Timberwolves' ensuing possession, setting up a 72-yard scoring strike from Alexander to Forrest with 2:51 left. Alexander's diving, two-point conversion run trimmed the lead to 37-36 before the Timberwolves ran out the game clock.
Alexander finished 17-of-29 for 221 yards, with Forrest corralling eight catches for 178 yards.
SC, which finished with just 141 rushing yard on 26 carries, was led by Haynes' 56 yards, while Cunningham added 46.
"We've been there before in situations where we've had to fight back," said Messinger. "I'm not worried that we don't have the potential to pick it up and have a real good season, but we're still in murderer's row here with our schedule
"We've just got to get refocused, coach the kids up and get back at it next week."
South Charleston will travels to Cabell Midland next week, while Spring Valley takes on Beckley at home.