Parkersburg accounted for the only blemish on Hurricane's record, playing the Redskins to a 1-1 tie late in the season.
The second-ranked Big Reds (16-3-4) have been erratic with results like that being offset by outcomes like a 2-0 loss to South Charleston and a 3-1 loss at Winfield.
George Washington won the regular season meeting 3-0 on Sept. 4.
"I think everybody's got a chance," Patriot Coach Tom Hopper said. "We have to control the ball, have patience, and a little bit of luck."
The fifth-ranked Patriots (16-5-2) are also a low-scoring bunch with just 52 goals on the season and are led by Noah Miller and Garrett Warner with 12 and 10 goals respectively.
Junior keeper Garrett Phillips has recorded 14 shutouts as George Washington has allowed less than a goal per game.
While the Patriots will be looking to repeat and pick up their third state soccer title, Parkersburg will be shooting for a seventh title in its first state tournament appearance since 2009.
The Big Reds have won the event six of the eight times in which they have qualified.
They are led by keeper Reid Strobl and the senior quartet of Zac Wilcoxen, Tyler Broadwater, Garrett Kruger and Cameron Morris.