News of the injury dominated social media. Joe Theismann whose NFL career ended with a horrific broken leg, said on Twitter, "Watching Duke/ Louisville my heart goes out to Kevin Ware.''
Fans chanted "Kevin! Kevin'' as Ware was loaded onto the stretcher, and Pitino wiped away tears again as Ware was wheeled off the court.
The Cardinals struggled to put the horrific injury behind them, missing four of their next five shots along with two free throws after play resumed. They regrouped after a timeout, with Smith's finger roll sparking a 12-6 run to finish the half that gave them a 35-32 lead.
Smith picked up where he left off at the start of the second half, making all three free throws after being fouled on a 3-point attempt to give Louisville a 38-32 lead, its largest of the game to that point.
But just as he did against Michigan State, Duke star Seth Curry got hot after halftime, making two 3s in the first three minutes. Mason Plumlee dunked to tie the game at 42.
That, however, was all Louisville needed. Clawing for every rebound, diving on the floor for loose balls and cranking the intensity up even higher on their ferocious defense, the Cardinals were not going to lose.
And everyone, Duke included, knew it.
Smith made a layup, Siva made a nice jumper at the top of the key and then followed with a layup. Just like that, the Cardinals were off on a 20-4 run that sealed the victory.