A drive later, linebacker Brandon Golson blitzed and hit quarterback Trevor Knight squarely in the back to force a fumble.
Cook's end-zone interception in the third quarter thwarted an 83-yard drive. Karl Joseph's interception one possession later came at WVU's 4-yard line after the Mountaineers threw an interception to give the ball back to OU.
Down 13-7, WVU ended up moving that ball to the OU 35 and looked like it had all the momentum when a short pass to Kevin White seemed to convert a third-and-20. White was hit from the side and lost a fumble.
"When we came out with the two key interceptions, that was big, and when we were moving the ball down the field there, I thought we were going to take the lead," Patterson said. "I told them, 'We're going to go back out there and we're going to be up a point.'"
WVU would force a punt and survive a series of special teams errors. Punt returner Mario Alford decided to fair catch the OU punt at his own 5.
Punter Nick O'Toole's 33-yard punt gave the Sooners the ball at the 38. Patterson's players came up with a three-and-out.
"The defense definitely played well enough for us to win," WVU offensive coordinator Shannon Dawson said. "You can't win a game scoring seven points, I don't care who you're playing. If your defense holds a team like Oklahoma to 16 points, you should win the game."
Patterson's unit was besieged by injuries along the way. Bruce left the game in the second quarter and did not return. The spur was replaced in the base defense by K.J. Dillon, a safety who was being used extensively as a nickel back in pass defense packages against Oklahoma formations.
Dillon then left in the third quarter, which really scrambled the plan for Patterson. He played junior Wes Tonkery in the pass package and freshman Marvin Gross in the base package.
"We just kept playing defense," said Patterson, who said he didn't change his approach much even with the personnel problems. "Playing with a freshman, that's a pretty big stage to be playing a kid on the perimeter of your defense.
"When K.J. went down after Isaiah went down, it made things a little harder on us. They tried to run the ball at (Gross) some, so we had to mix some things up, but I thought Marvin, for being thrown into that particular situation, did all right with a tough task."
Contact sportswriter Mike Casazza at mi...@dailymail.com or 304-319-1142. His blog is at blogs.dailymail.com/wvu.