Poca (1-7), like many teams Wayne has faced this season, struggled to match the Pioneers throughout.
"Wayne's going through that period of time where they got some really good athletes and a good program going there," Dots coach Bob Lemley said. "They're fast, they're strong, they're a good football team. I don't know who can handle them. They're pretty tough."
Wayne extended its state-best winning streak to 31 games. Ferguson said the team takes pride in adding to its victory total and taking one more step toward its third consecutive state championship.
"That just means the world," he said. "If we could go undefeated again, that's just something special. It would just be a gift and hopefully we can do that, and the way we're on right now, I think we can if we keep working together."
Lemley said it will be tough for any opponent to stop the Pioneers' run.
"Right now, they have a lot of things that you need to have a championship football team," he said. "They have all the ingredients. It's just a matter sometimes of pick your poison with them."
Wayne recorded 401 total yards in the first half, with 173 via the pass, as the Pioneers starters played the first 11/2 quarters before giving way to the reserves. Wayne scored on each of its first seven possessions to take a commanding lead.
Clendenin scored on a 5-yard touchdown, Poca's lone first-half score, with 5:45 left in the second quarter.
Wayne visits Chapmanville next Friday while Poca plays at Sissonville.