That's not to say it was an easy decision. Glasnow said he mulled it over for a while before signing the deal.
"I was pretty set on school," the 19-year-old Glasnow said. "Every day went by, and I leaned toward pro ball more and more and more."
It didn't hurt that Pittsburgh offered Glasnow a $600,000 signing bonus, which was the biggest known deal outside of the top 65 picks in that draft. Ryan said the Twins offered him an enticing sum, too. He never figured he'd get picked that early and didn't want to run the risk of falling in later drafts.
"My dream was always to play in the big leagues and that was the way to start right away," he said.
Ryan realized those dreams, playing 149 Major League games over five seasons. Glasnow is working his way up the Pirates system, getting voted into this year's South Atlantic League All-Star Game.
For Blair, the choice likely will be an easy one. For many other prospects, it won't. Ryan's advice to those young players is to go with their gut.
"You have to trust your gut feeling," Ryan said. "If you think it's the right thing to do, then you should do it. What I did was I weighed what good could come out of it and what bad could come out of it, and if the good outweighed it, I was going to do it. It worked out for me."
Contact sportswriter Derek Redd at derek.r...@dailymail.com or 304-348-1712. His blog is at blogs.dailymail.com/marshall. Follow him on Twitter @derekredd.