Class AAA girls - With six runners rated in the top 14, Morgantown is expected to claim the championship with relative ease.
Defending champ Victoria Cooke and teammate Brynn Harshbarger are expected to contend for the individual title, as well as University's Amelia Paladino and several others.
As everyone else races for second, Hurricane will battle University as the favorites to finish behind Morgantown.
Junior Tori Dent, who is expected to finish in the top 10, leads a rather deep Redskins team.
In the next tier of teams, Winfield and Midland will fight for a spot in the state's top five.
Meanwhile, Capital, Greenbrier East and Shady Spring will race representing Region 3.
Capital sophomore Peyton Panger will be expected to finish among the state's top 10, while Generals runner Brittney McMillion, Midland's Jorden Thornton and Hurricane senior Emily Schwendiman could also place top 10 with an outstanding effort.
Class AA-A boys - Fairmont Senior is the favorite to win the team championship, with Philip Barbour, Frankfort, Bridgeport and Doddridge County following. In addition, Buffalo and Charleston Catholic are expected to finish in the top half of the standings and possibly contend for a top 5 spot.
Individually, Fairmont Senior's Nick Trefz should win comfortably. Behind Trefz, Scott's Will Shaffer will be among several contenders racing for second.
Catholic senior Marcus Black, rated fifth in the state, said he's ready to leave his mark, too.
Last season, Black finished 11th as he faltered in the final stretch of the state meet. This season, Black said he's worked to overcome any possible late race letdown.
"All season I've been finishing strong, I've had a kick," he said. "I don't think I've been passed up at all in the last 400 meters of any race this year. Hopefully, I can keep it that way Saturday."
For Buffalo, like Black with Catholic, Dylan Rich will aim for a top 10 spot, too, as he leads the Bison.
Class AA-A girls - While Philip Barbour should win its third title in a row, Scott will battle Frankfort and possibly others for second place.
Scott defeated Ravenswood for the Region 4 championship, as both teams advanced to the State Meet. Scott should contend for second place, while Ravenswood is expected to finish closer to the middle of the pack of the 12 teams competing.
There will be no drama for first place individually as St. Marys senior Maggie Drazba is expected to win by a minute or more.
Among the best locally, Ravenswood's Hailey Miller is expected to contend for a top 10 spot, as will Scott's Brittany Green.