Jackson added two more touchdown runs before the Big Reds could get on the board with a 27-yard Josh Roney field goal with 3:50 left in the first half.
Parkersburg fumbled four times, losing two, and quarterback Aaron Roberts was intercepted once while completing just 1 of 10 passes. The Big Reds did move the ball well on the ground, picking up 260 yards, but the turnovers kept them from ever gaining any momentum.
"That's kind of haunted us the whole year. We make plays and then we turn around and hurt ourselves with turnovers," Parkersburg coach Don Reeves said. "Sometimes we hurt ourselves more than teams hurt us."
The Patriots were particularly effective at punishing Big Red mistakes in the second and third quarters, when they outscored Parkersburg 41-10. Quarterback Jon Alexander, who completed 3 of 7 passes for 85 yards and a 63-yard touchdown pass to Austin Giacomo, also called his own number on a quarterback draw and scored on a 35-yard run just before halftime.
Still, Edwards said he saw room for improvement in his team, which faces Ripley at home next week.
"We're still not satisfied yet," he said. "We've got a lot of work to do but we keep getting kids banged up here and there, but the kids are playing hard and doing what they have to do to win."
Burdette led Parkersburg with 79 rushing yards, while Alexander added 52 for GW.