Forward Kevin Jones, who is bothered by a leg injury, had six points and five rebounds, but took just two shots in 16 minutes.
Yann Charles and Coron Williams had 11 points each for the Colonials (3-5), who were outrebounded, 48-25, and outscored in the paint, 44-8.
WVU shot 55.8 percent in the game and 63.3 percent in the second half (19-for-30), when it outscored RMU, 50-21.
"We weren't running the offense early on," Mazzulla said. "You notice in the second half we made five, six, seven passes and got them out of their defensive rotations and made easy cuts to the basket. The game is easy when you move the ball. The first half the offense was stagnant, like it has been most of the year."
The Mountaineers made 15 of their first 18 shots after halftime and cleared up shaky play with 12 assists and just two turnovers to take a 68-41 lead. The margin would grow to 37 points, but for long stretches it was not as easy.
The Colonials, picked to finish second in the Northeast Conference preseason poll, led twice in the first half and never trailed by more than six points. They had several simple paths to the basket and took advantage with layups, but also missed a dunk and a handful of other close looks. They also insisted on shooting 3-pointers and missed 10 of 13, though only trailed 32-28 at halftime.
RMU's Russell Johnson rattled in a 3 to start the second half and none of Bryant's teammates bothered to help him with the inbound.
Huggins removed Bryant, Flowers, Jones, Casey Mitchell and Dan Jennings - Jones, Mitchell and Jennings wouldn't return - and put in Kilicli, Mazzulla, Dalton Pepper, Cam Thoroughman and Jonnie West.
Pepper scored on the left baseline, Kilicli scored inside and Mazzulla drove for a layup to force RMU to take a timeout after 1:40. Thoroughman then lobbed a pass to Mazzulla for a layup and Mazzulla later slipped a pass inside to Kilicli for another basket. Thoroughman forced a turnover before Mazzulla and Kilicli connected again. West made a 3 to end the run and push the lead to 47-35.
In the 10 possessions together, the second team was 7-for-8 with five assists and two turnovers. Pepper was 1-for-2, West 1-for-1, Mazzulla 2-for-2 with three assists and Kilicli 3-for-3. Thoroughman didn't score, but had two assists.
"That meant a lot to me," Bryant said. "Honestly, I'm happy Huggs took us out. The first five wasn't playing hard, I don't think, and that's why I was trying to be aggressive at the beginning of the game. But everyone was walking around at times, including myself, and we couldn't get it going. I'm happy Huggs put a new five in."