Two days after a dreadful shooting performance led to the third-lowest point total in 132 games with Bob Huggins, the 25th-ranked Mountaineers were outrebounded by 12, outscored in the paint by 18 and outplayed in the areas that mattered most Monday.
No. 4 Pitt followed four players who scored in double figures to replace injured leading scorer Ashton Gibbs and beat WVU, 71-66, before 14,174 inside the Coliseum.
"They outmanned us, is what happened," Huggins said. "They just beat us to death on the offensive glass and drove it where they wanted to drive it. They just outmanned us."
The Panthers (22-2, 10-1 Big East) matched their best start in Big East play by scoring points on 25 of their 30 possessions in the second half.
The five empty possessions were three turnovers, one one-shot possession where WVU grabbed the defensive rebound and two missed free throws on Pitt's final possession.
"They probably took two or three jump shots the entire second half," said WVU point guard Joe Mazzulla. "The rest of it was layups and second-chance points."
Pitt shot 60.7 percent in the second half, one game after Villanova shot 60 percent against WVU in the second half of their game. Of Pitt's 48 second-half points, 26 came in the paint, 12 came on offensive rebounds and 13 came at the free-throw line.
The nation's No. 1 team in rebounding margin finished with a 40-28 advantage, including 18-8 in offensive rebounds.
"It definitely wore on us," said WVU forward Kevin Jones.
"They're a smart team. They didn't take any rushed shots. After they got a rebound, they'd pass it out and run the offense again. It's all a part of them being the best team in the Big East. We have to learn from this and grow from it and if we don't get better from it, it's just a bad experience."
WVU (15-8, 6-5) lost for the fourth time in seven games and failed to reach 70 points for the sixth consecutive game, the longest streak in four seasons under Huggins and the worst since seven in a row since the 2005 season.
A win Saturday at Villanova would have pushed the Mountaineers into a tie for second place in the standings.
They're now in eighth before Saturday's home game against DePaul (6-16, 0-10), one of two opponents in the final seven regular-season games that isn't ranked.
"We're outmanned," Huggins said. "I can't trade them. I could waive them, I guess, but I wouldn't get anybody for them. I could sit here and lie to you, but I'm not going to lie to you. We just got outmanned."