Kevin Jones, who had one of the team's two baskets that wasn't a layup or a 3-pointer, had eight points and Dalton Pepper added nine.
"A pressing team can lose track of shooters and Casey and Pep got free and hit some 3s between the two of them," Mazzulla said. "When that happens you get penetration and because their guys come out you can throw it in for layups."
DePaul lost its 25th straight game against a Big East opponent, 24 of which have been in the regular season. The loss to WVU was the 29th in a row on the road and the 27th in a row against a ranked team.
"I'm sure it grinds on them," first-year Coach Oliver Purnell said. "We've been playing better and better, just not playing good enough to win or close out games. They've done an outstanding job in the face of a lot of adversity. It's tough to take for anyone."
Brandon Young was in foul trouble and played just 20 minutes, but led the team with 13 points. Jimmy Drew had 13 and Krys Faber and Tony Freeland both had 11. DePaul was 15-for-24 in the second half and shot 25-for-49 in the game.
"I didn't really get the feeling that our guys believed in the first half," Purnell said. "They got to the point where they believed in the second half and we did a much better job with our offense. We shot the ball really well, but defensively, we didn't do our job on the backboard."
WVU outrebounded DePaul 30-26 and rebounded 12 of its 25 missed shots.
The Mountaineers made their mark in the first half with 17 baskets, 12 layups and 15 assists. Everyone had at least two baskets, except Kilicli, who dunked on his only shot. They had just four turnovers and finished the game with 11 after committing 16 at DePaul last month.
"We're one of the top teams in the conference when we move the ball," Mitchell said. "When we don't move the ball and we take the early shots, we're not too good. But if we move the ball, we can beat anybody."
WVU plays at 7 p.m. Monday at No. 12 Syracuse (20-6, 7-6), which lost Saturday to No. 16 Louisville, 73-69. The Mountaineers are 1-8 all-time against the Orange at the Carrier Dome with eight straight losses, but won Sweet Sixteen and Elite Eight games in the NCAA Tournament there last March and can at least feel better about their offensive performance before Big Monday.
"It's good for everyone's confidence to have that many scorers and that many people hitting shots going into Syracuse," Mitchell said. "The Syracuse game is going to be a big environment, but this was a big confidence-boost game."
Contact sportswriter Mike Casazza at mi...@dailymail.com or 304-319-1142. His blog is at blogs.dailymail.com/wvu.