Texas Tech (21-9, 11-7) and Oklahoma State (20-9, 9-9), the other teams on Baylor's side of the bracket, play Saturday morning.
The Sooners have won their last two games, the league's next-longest winning streak behind Baylor.
"Within our conference, we have a lot of good teams and when good teams beat good teams, they don't get ranked," said Oklahoma's Joanna McFarland, the league's top rebounder (9.9 per game). "You can be in a bad conference and win every game, and you're going to get ranked. ... Our conference prepares us well for going out and facing teams."
Baylor has won 27 in a row overall since a two-point loss to fourth-ranked Stanford a week into this season when All-American point guard Odyssey Sims was hurt. The Lady Bears are 3-0 against other Top 10 teams, winning by an average margin of 23 points.
Kansas State, which has lost five players to season-ending injuries, lost 90-68 on Monday night at Baylor when Griner scored a Big 12-record 50 points and had her 14th career dunk.
The Wildcats were within 63-60 before a 23-2 Baylor run, but aren't yet thinking about possibly having to face the Lady Bears again.
"A team that's depleted in terms of injuries and size like ours, we're really just all about preparation for the next game," K-State coach Deb Patterson said. "Throwing pity parties or feeling down and out, I just think these young people love to compete. They're tough-minded."
Kansas was also 8-10 in the Big 12 last season, and didn't win a game in the conference tournament before advancing to the NCAA round of 16. The Jayhawks open this week's conference tournament against TCU, whose only two league wins were against teams ranked No. 23 at the time - Oklahoma State and Iowa State.
Semifinal games are Sunday. The championship game is Monday night, a game likely to include Baylor and all their seniors, though Mulkey won't let them take that for granted.
"Their experience should tell them ... no one's just going to come out there and hand it to you," Mulkey said. "You have to play well every night, particularly when people are really gunning for you because you're the No. 1 team in the country, you're the defending national champion. You're going to get everybody's best shot. I think our players have handled themselves well."