Place the pill as far back in the mouth as possible, avoiding the tongue at all costs. If she tastes the pill, the drooling will soon start and she will turn into that slimy drool producer you referred to in your question.
Now, let go of her head after you place the pill in the back of her mouth, and watch for lip licking motions that usually indicate the pill has been swallowed. At this point you can squirt a small amount of water into her mouth to help her swallow the pill. Just a little water will do. If you give too much, she will definitely struggle with you and you will get spit on by your own cat. (A story not to share with others.) Now it is safe to give another treat to her and gently release your hold on her peacefully.
Does this seem impossible? It can be done. I have seen it and participated when needed. But if she is just getting more and more resistant, there are other options to try. One is an injectable antibiotic shot that continues to work for seven days. It is more expensive, but a nice option for wilder cats and especially the outdoor ones from the neighborhood.
Some antibiotics come in liquid form, which can be easier for owners and cats. You still have to give it twice daily by mouth, but there are cats who do better with this form. Liquids can even be flavored to taste like tuna or chicken so the cats do like to take their medicine. This is ideal. Flavoring happens at human compounding pharmacies, and there is an additional cost with this preparation.
Another option for some medicine is a transdermal approach. A compounding pharmacist can turn your medicine into a paste that you rub onto the inner part of your cat's ear. It is absorbed and the cat gets treated.
But if all this fails, your cat is still sick, half of your medicine has been wasted and you both are wounded, talk to your veterinarian. Almost all hospitals will allow you to bring your pet in twice daily for a technician to medicate your cat. If there is a will, there is a way to fix your cat.
Send questions for Dr. Allison Dascoli to "Ask the Vet," Charleston Daily Mail, 1001 Virginia St. E., Charleston WV 25301 or email them to askthe...@dailymail.com. Comments or suggestions can be submitted the same way.